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Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson PDF

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

ISBN-10: 9048158818

ISBN-13: 9789048158812

ISBN-10: 9401597219

ISBN-13: 9789401597210

This quantity is the lawsuits of the eleventh foreign convention on Advances in Prostaglandin and Leukotriene examine: uncomplicated technology and New medical purposes, held in Florence, Italy, on June 4-8, 2000, which keeps the culture of masking either easy and medical points of prostaglandin and leukotriene learn.

At this assembly specific emphasis was once given to the aptitude software of the radical COX-2 inhibitors, the genetics of bronchial asthma with regards to the construction of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.

Traditionally, as has been performed in previous conferences of this sequence, a large amount of new fabric was once awarded and mentioned this yr, with specific awareness given to the latest scientific data.

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Additional info for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

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Selenium-dependent inhibition of 5-LO activity of intact cells and cell homogenates from HL-60, BL41-E95A and Mono Mac 6 cells. Cells were cultured under the indicated culture conditions. Then, 5-LO activity of intact cells and cell homogenates was determined in the absence of exogenously added thiols. However, when 5-LO activity was determined in the corresponding cell homogenates in the absence of exogenously added thiols, there was a similar 5-LO activity under all cell culture conditions in HL-60 cells and in BL41-E95A cells, respectively.

18. 19. 20. 21. 22. Soderstrom M, Bolling A, Hammarstrom S. Induction ofleukotriene C4 synthase activity in differentiating human erythroleukemia cells. Biochem Biophys Res Commun 1992; 189:1043-49. Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cellline, THP-1. J Immunol 1999; 162:1101-7. , Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP.

This reversal of 5-LO distribution pattern could reflect either export of 5-LO molecules formerly found in the nucleoplasm, or tumover of the intranuclear 5-LO and a failure to import into the nucleus the newly synthesized polypeptide molecules. In preliminary experiments, the nuclear export inhibitor leptomycin failed to prevent this redistribution over time, suggesting a failure of import in cells removed from the alveolus. On the basis ofthese observations, we suggest that factors unique to the alveolar milieu favor nuclear accumulation of 5-LO, primarily by promoting nuclear import.

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Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)


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