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C. Wrong test: Sometimes we find severe necrosis in a primary dermal irritation study or irritation (but no corrosion) in a corrosivity test. In the former, we can grade the material as a severe irritant but cannot make an evaluation as to its (as defined by regulation) corrosive potential. In the latter case, we can judge the material as not corrosive and to have irritating potential. The difference is, of course, in the length of the exposure period (though more recent EPA guidelines suggest making both tests of 4 hr in length).

M. ), pp. 169-174. Liebert, New York. Gilman, M. R. (1982). Skin and eye testing in animals. In Principles and Methods of Toxicology (A. W. ), pp. 209-222. Raven Press, New York. Gordon, V. , Kelly, C. , and Bergman, H. C. (1989). SKINTEX, an in vitro method for determining dermal irritation. International Congress of Toxicology, Brighton, UK. Gordon, V. , Kelly, C. , and Bergman, H. C. (1990). Evaluation of SKINTEX, an in vitro method for determining dermal irritation. Toxicologist 10(1), 78. Guillot, J.

Reinhardt, C. , and Spengler, J. (1987). Validation of three cell toxicity tests and the hen's egg test with guinea pig eye and human skin irritation data. In Alternative Methods in Toxicology (A. M. ), Vol. 5. Liebert, New York. , Akers, W. , McCreesh, A. , and Maibach, H. I. (1975).

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Acute toxicology


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